Effect of induced high myopia on functional MRI signal changes

•In myopic state, fMRI BOLD signal reduced in occipital visual cortex.•BOLD signal reduction also depends to spatial frequency of visual stimulus.•More myopic power is not associated with more BOLD signal reduction. The current study evaluated the effect of lens-induced high myopia (IHM) on the activity of the occipital visual cortex during two visual stimuli presentations to the subjects. This was done by measuring the Blood Oxygenation Level Dependent (BOLD) signal using functional MRI (fMRI). BOLD contrast fMRI was performed with a 1.5T MRI scanner on 12 emmetropic subjects (refractive error