Engineering RGB color vision into Escherichia coli
A synthetic biology system composed of light-wavelength-responsive genetic regulators, signal-processing circuits and pigment-production pathways have resulted in an Escherichia coli strain that can record color images in RGB format. Optogenetic tools use colored light to rapidly control gene expres...
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Veröffentlicht in: | Nature chemical biology 2017-07, Vol.13 (7), p.706-708 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A synthetic biology system composed of light-wavelength-responsive genetic regulators, signal-processing circuits and pigment-production pathways have resulted in an
Escherichia coli
strain that can record color images in RGB format.
Optogenetic tools use colored light to rapidly control gene expression in space and time. We designed a genetically encoded system that gives
Escherichia coli
the ability to distinguish between red, green, and blue (RGB) light and respond by changing gene expression. We use this system to produce 'color photographs' on bacterial culture plates by controlling pigment production and to redirect metabolic flux by expressing CRISPRi guide RNAs. |
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ISSN: | 1552-4450 1552-4469 |
DOI: | 10.1038/nchembio.2390 |