Anthelmintic activity of cytochrome P450 inhibitors miconazole and clotrimazole: in-vitro effect on the liver fluke Opisthorchis felineus
Highlights • Miconazole and clotrimazole have anthelminthic activity against juvenile worms. • Activity of miconazole and clotrimazole was comparable to that of praziquantel. • Miconazole caused 100% mortality among juvenile worms. • Miconazole caused paralysis, excretory system deformation and surf...
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| Veröffentlicht in: | International journal of antimicrobial agents 2017-07, Vol.50 (1), p.97-100 |
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| container_title | International journal of antimicrobial agents |
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| creator | Mordvinov, Viatcheslav A Shilov, Alexander G Pakharukova, Maria Y |
| description | Highlights • Miconazole and clotrimazole have anthelminthic activity against juvenile worms. • Activity of miconazole and clotrimazole was comparable to that of praziquantel. • Miconazole caused 100% mortality among juvenile worms. • Miconazole caused paralysis, excretory system deformation and surface blebbing. |
| doi_str_mv | 10.1016/j.ijantimicag.2017.01.037 |
| format | Article |
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| identifier | ISSN: 0924-8579 |
| ispartof | International journal of antimicrobial agents, 2017-07, Vol.50 (1), p.97-100 |
| issn | 0924-8579 1872-7913 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anthelmintics - pharmacology Biological Assay Clotrimazole - pharmacology Cytochrome P-450 Enzyme Inhibitors - pharmacology Cytochrome P450 Drug metabolism Flatworms Infectious Disease Inhibitory Concentration 50 Locomotion - drug effects Miconazole - pharmacology Opisthorchis - drug effects Opisthorchis felineus Parasitic Sensitivity Tests Survival Analysis |
| title | Anthelmintic activity of cytochrome P450 inhibitors miconazole and clotrimazole: in-vitro effect on the liver fluke Opisthorchis felineus |
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