Anthelmintic activity of cytochrome P450 inhibitors miconazole and clotrimazole: in-vitro effect on the liver fluke Opisthorchis felineus

Highlights • Miconazole and clotrimazole have anthelminthic activity against juvenile worms. • Activity of miconazole and clotrimazole was comparable to that of praziquantel. • Miconazole caused 100% mortality among juvenile worms. • Miconazole caused paralysis, excretory system deformation and surf...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-07, Vol.50 (1), p.97-100
Hauptverfasser:	Mordvinov, Viatcheslav A, Shilov, Alexander G, Pakharukova, Maria Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - pharmacology Biological Assay Clotrimazole - pharmacology Cytochrome P-450 Enzyme Inhibitors - pharmacology Cytochrome P450 Drug metabolism Flatworms Infectious Disease Inhibitory Concentration 50 Locomotion - drug effects Miconazole - pharmacology Opisthorchis - drug effects Opisthorchis felineus Parasitic Sensitivity Tests Survival Analysis
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Beschreibung
Zusammenfassung:	Highlights • Miconazole and clotrimazole have anthelminthic activity against juvenile worms. • Activity of miconazole and clotrimazole was comparable to that of praziquantel. • Miconazole caused 100% mortality among juvenile worms. • Miconazole caused paralysis, excretory system deformation and surface blebbing.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2017.01.037