Clinical Impact of Colonization with Multidrug-Resistant Organisms on Outcome after Autologous Stem Cell Transplantation: a Retrospective Single Center Study

Highlights • Colonization with MDRO lead to an inferior overall survival • Main cause of death is infection in colonized patients • There was no difference in Non-relapse mortality during neutropenia • The period following discharge after transplantation seems most critical

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Bibliographische Detailangaben
Veröffentlicht in:	Biology of blood and marrow transplantation 2017-09, Vol.23 (9), p.1455-1462
Hauptverfasser:	Scheich, Sebastian, Reinheimer, Claudia, Brandt, Christian, Wichelhaus, Thomas A, Hogardt, Michael, Kempf, Volkhard A.J, Brunnberg, Uta, Brandts, Christian, Ballo, Olivier, von Metzler, Ivana, Kessel, Johanna, Serve, Hubert, Steffen, Björn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis of Variance Anti-Bacterial Agents - therapeutic use Autologous stem cell transplantation Colonization Drug Resistance, Multiple, Bacterial Female Gram-Negative Bacterial Infections - immunology Gram-Negative Bacterial Infections - microbiology Gram-Negative Bacterial Infections - mortality Gram-Negative Bacterial Infections - therapy Gram-Positive Bacterial Infections - immunology Gram-Positive Bacterial Infections - microbiology Gram-Positive Bacterial Infections - mortality Gram-Positive Bacterial Infections - therapy Hematologic Neoplasms - immunology Hematologic Neoplasms - microbiology Hematologic Neoplasms - mortality Hematologic Neoplasms - therapy Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Multidrug-resistant organisms Myeloablative Agonists - therapeutic use Neutropenia - immunology Neutropenia - microbiology Neutropenia - mortality Neutropenia - therapy Retrospective Studies Survival Analysis Transplantation Conditioning - methods Transplantation, Autologous Transplantation, Homologous Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • Colonization with MDRO lead to an inferior overall survival • Main cause of death is infection in colonized patients • There was no difference in Non-relapse mortality during neutropenia • The period following discharge after transplantation seems most critical
ISSN:	1083-8791 1523-6536
DOI:	10.1016/j.bbmt.2017.05.016