Maintenance of claudin-3 expression and the barrier functions of intercellular junctions in parotid acinar cells via the inhibition of Src signaling

Highlights • Claudin-4, a duct claudin, transiently increased in γ-irradiated parotid glands. • Changes of claudins occur in common between in vivo and in vitro by tissue injuries. • Loss of claudin-3 and E-cadherin causes barrier dysfunction even if occludin remains. • Src inhibition suppresses dec...

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Veröffentlicht in:	Archives of oral biology 2017-09, Vol.81, p.141-150
Hauptverfasser:	Yokoyama, Megumi, Narita, Takanori, Sakurai, Hajime, Katsumata-Kato, Osamu, Sugiya, Hiroshi, Fujita-Yoshigaki, Junko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - metabolism Advanced Basic Science Animals Cadherins - metabolism Cells, Cultured Claudin-3 - metabolism Dentistry Immunoblotting Intercellular Junctions - metabolism Irradiation Male Occludin - metabolism Paracellular permeability Parotid Gland - metabolism Parotid Gland - radiation effects Primary culture Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Salivary glands Signal Transduction src-Family Kinases - metabolism Tight junctions
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Zusammenfassung:	Highlights • Claudin-4, a duct claudin, transiently increased in γ-irradiated parotid glands. • Changes of claudins occur in common between in vivo and in vitro by tissue injuries. • Loss of claudin-3 and E-cadherin causes barrier dysfunction even if occludin remains. • Src inhibition suppresses decrease in claudin-3 and disruption of intercellular barrier.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2017.05.007