Acute kidney injury risk associated with piperacillin/tazobactam compared with cefepime during vancomycin therapy in hospitalised patients: a cohort study stratified by baseline kidney function

Highlights • Risk of AKI with vancomycin + piperacillin/tazobactam (VPT) versus vancomycin + cefepime (VC) was compared. • Elevated risk of AKI in hospitalised patients receiving VPT was compared with VC. • Association was true in patients with normal renal function but not in those with pre-existin...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-07, Vol.50 (1), p.63-67
Hauptverfasser:	Jeon, Nakyung, Staley, Ben, Klinker, Kenneth P, Hincapie Castillo, Juan, Winterstein, Almut G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute kidney injury Acute Kidney Injury - chemically induced Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - adverse effects beta-Lactamase Inhibitors - adverse effects Cephalosporins - adverse effects Drug Therapy, Combination - adverse effects Female Humans Infectious Disease Inverse probability of treatment weighting IPTW Male Middle Aged Penicillanic Acid - adverse effects Penicillanic Acid - analogs & derivatives Piperacillin - adverse effects Piperacillin/tazobactam Renal impairment Retrospective Studies Risk Assessment Vancomycin Vancomycin - adverse effects Young Adult
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Zusammenfassung:	Highlights • Risk of AKI with vancomycin + piperacillin/tazobactam (VPT) versus vancomycin + cefepime (VC) was compared. • Elevated risk of AKI in hospitalised patients receiving VPT was compared with VC. • Association was true in patients with normal renal function but not in those with pre-existing renal impairment. • Future studies evaluating drug-associated AKI should consider stratification by baseline renal function.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2017.02.023