Insulin-induced inhibition of gluconeogenesis genes, including glutamic pyruvic transaminase 2, is associated with reduced histone acetylation in a human liver cell line

Abstract Objectives Hepatic glutamic pyruvic transaminase (GPT; also known as alanine aminotransferase) is a gluconeogenesis enzyme that catalyzes conversions between alanine and pyruvic acid. It is also used as a blood biomarker for hepatic damage. In this study, we investigated whether insulin reg...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2017-06, Vol.71, p.118-124
Hauptverfasser:	Honma, Kazue, Kamikubo, Michiko, Mochizuki, Kazuki, Goda, Toshinao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Alanine Transaminase - metabolism Cell Line Dose-Response Relationship, Drug Endocrinology & Metabolism Gene Expression Regulation - drug effects Gluconeogenesis - drug effects Gluconeogenesis - genetics Histones - metabolism Humans Hypoglycemic Agents - pharmacology Insulin - pharmacology Liver - cytology Liver - metabolism
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