MicroRNA-203 inhibits proliferation and invasion, and promotes apoptosis of osteosarcoma cells by targeting Runt-related transcription factor 2

Highlights • MicroRNA-203 acts as a suppressor gene in osteosarcoma. • MicroRNA-203 inhibits osteosarcoma cells proliferation by directly down-regulating RUNX2. • MicroRNA-203 promotes osteosarcoma cells apoptosis by directly down-regulating RUNX2. • MicroRNA-203 inhibits osteosarcoma cells invasion...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-07, Vol.91, p.1075-1084
Hauptverfasser:	Lin, Wenjun, Zhu, Xiongbai, Yang, Shengwu, Chen, Xin, Wang, Lu, Huang, Zhengxiang, Ding, Yewei, Huang, Lintuo, Lv, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Core Binding Factor Alpha 1 Subunit - genetics Gene Expression Regulation, Neoplastic - genetics Humans Internal Medicine Invasion Medical Education MicroRNA-203 MicroRNAs - genetics Neoplasm Invasiveness - genetics Osteoblasts - pathology Osteosarcoma Osteosarcoma - genetics Proliferation RUNX2
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Zusammenfassung:	Highlights • MicroRNA-203 acts as a suppressor gene in osteosarcoma. • MicroRNA-203 inhibits osteosarcoma cells proliferation by directly down-regulating RUNX2. • MicroRNA-203 promotes osteosarcoma cells apoptosis by directly down-regulating RUNX2. • MicroRNA-203 inhibits osteosarcoma cells invasion by directly down-regulating RUNX2.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2017.05.034