MicroRNA-203 inhibits proliferation and invasion, and promotes apoptosis of osteosarcoma cells by targeting Runt-related transcription factor 2
Highlights • MicroRNA-203 acts as a suppressor gene in osteosarcoma. • MicroRNA-203 inhibits osteosarcoma cells proliferation by directly down-regulating RUNX2. • MicroRNA-203 promotes osteosarcoma cells apoptosis by directly down-regulating RUNX2. • MicroRNA-203 inhibits osteosarcoma cells invasion...
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Veröffentlicht in: | Biomedicine & pharmacotherapy 2017-07, Vol.91, p.1075-1084 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • MicroRNA-203 acts as a suppressor gene in osteosarcoma. • MicroRNA-203 inhibits osteosarcoma cells proliferation by directly down-regulating RUNX2. • MicroRNA-203 promotes osteosarcoma cells apoptosis by directly down-regulating RUNX2. • MicroRNA-203 inhibits osteosarcoma cells invasion by directly down-regulating RUNX2. |
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ISSN: | 0753-3322 1950-6007 |
DOI: | 10.1016/j.biopha.2017.05.034 |