Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats

Highlights • PENFS with BRIDGE device prevented and attenuated post-inflammatory visceral and somatic hyperalgesia in rats. • After PENFS, amygdala neurons had a significant reduction in spontaneous firing and response to somatic stimulation. • PENS also significantly attenuated firing of neurons in...

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Veröffentlicht in:	Neuroscience 2017-07, Vol.356, p.11-21
Hauptverfasser:	Babygirija, Reji, Sood, Manu, Kannampalli, Pradeep, Sengupta, Jyoti N, Miranda, Adrian
Format:	Artikel
Sprache:	eng
Schlagworte:	amygdala Animals auricular stimulation colitis Disease Models, Animal Hyperalgesia - physiopathology Hyperalgesia - therapy Inflammation - physiopathology Male Neurology Neurons - drug effects Neurons - metabolism Rats, Sprague-Dawley Spinal Cord - drug effects Spinal Cord - physiopathology spinal neurons Transcutaneous Electric Nerve Stimulation - methods Trinitrobenzenesulfonic Acid - pharmacology visceral hyperalgesia Visceral Pain - physiopathology Visceral Pain - therapy
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Zusammenfassung:	Highlights • PENFS with BRIDGE device prevented and attenuated post-inflammatory visceral and somatic hyperalgesia in rats. • After PENFS, amygdala neurons had a significant reduction in spontaneous firing and response to somatic stimulation. • PENS also significantly attenuated firing of neurons in the lumbar spinal dorsal horn region.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.05.012