Risk of low birth weight and micronutrient deficiencies in neonates from mothers after gastric bypass: A case control study
Abstract Background An increased risk of small-for-gestational-age infants after maternal bariatric surgery has been shown. The risk of micronutrients deficiencies in these neonates is unclear. Objective To screen for micronutrients deficiencies in newborns of mothers with gastric bypass Settings Un...
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| Veröffentlicht in: | Surgery for obesity and related diseases 2017-08, Vol.13 (8), p.1384-1391 |
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| creator | Gascoin, Geraldine, M.D., Ph.D Gerard, Maxime, M.D Sallé, Agnès, M.D., Ph.D Becouarn, Guillaume, M.D Rouleau, Stephanie, M.D Sentilhes, Loïc, M.D., Ph.D Coutant, Régis, M.D |
| description | Abstract Background An increased risk of small-for-gestational-age infants after maternal bariatric surgery has been shown. The risk of micronutrients deficiencies in these neonates is unclear. Objective To screen for micronutrients deficiencies in newborns of mothers with gastric bypass Settings University Hospital in Angers, France Methods This study compared the clinical and cord blood biological characteristics of 56 newborns of mothers with prior gastric bypass (RYGB) and 56 newborns of non-obese healthy mothers after normal pregnancy (controls), followed between 01/03/2008 and 31/10/2012. Cord blood micronutrients concentrations from controls were used for establishing normative data. After RYGB, the women took daily micronutrients supplements. Results RYGB mothers lost 18.1±6.3 kg/m2 of Body Mass Index (BMI) in the 11-69 months between surgery and pregnancy onset (percentage of excess weight loss 79±20%), reaching BMI of 30.1±6.0 kg/m2 compared with 22.3±4.0 kg/m2 in the controls (p |
| doi_str_mv | 10.1016/j.soard.2017.03.017 |
| format | Article |
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The risk of micronutrients deficiencies in these neonates is unclear. Objective To screen for micronutrients deficiencies in newborns of mothers with gastric bypass Settings University Hospital in Angers, France Methods This study compared the clinical and cord blood biological characteristics of 56 newborns of mothers with prior gastric bypass (RYGB) and 56 newborns of non-obese healthy mothers after normal pregnancy (controls), followed between 01/03/2008 and 31/10/2012. Cord blood micronutrients concentrations from controls were used for establishing normative data. After RYGB, the women took daily micronutrients supplements. Results RYGB mothers lost 18.1±6.3 kg/m2 of Body Mass Index (BMI) in the 11-69 months between surgery and pregnancy onset (percentage of excess weight loss 79±20%), reaching BMI of 30.1±6.0 kg/m2 compared with 22.3±4.0 kg/m2 in the controls (p<0.05). Neonates born to RYGB mothers were small-for-gestational-age in 23% of cases vs. 3.6% in the control group (p<0.01). A higher percentage of RYGB neonates had cord blood concentrations below the 2.5th percentile for calcium (19% vs 2%), zinc (13% vs 3%,), iron (19% vs 2%), and vitamin A (13% vs 3%), and over the 97.5th percentile for magnesium (13% vs 3%), vitamin E (16% vs 3%), 25-hydroxy-vitamin D (13% vs 2%), and vitamin B12 (14% vs 2%)(p<0.05 for all comparisons). Conclusion Neonates from RYGB mothers showed cord blood micronutrient differences as compared to neonates from healthy mothers. The comparison with neonates from morbidly obese women is still to be done.</description><identifier>ISSN: 1550-7289</identifier><identifier>EISSN: 1878-7533</identifier><identifier>DOI: 10.1016/j.soard.2017.03.017</identifier><identifier>PMID: 28526433</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Bariatric ; Case-Control Studies ; Female ; Fetal Blood - chemistry ; Gastric Bypass ; Gastroenterology and Hepatology ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age ; Micronutrient ; Micronutrients - deficiency ; Middle Aged ; Morbid obesity ; Neonate ; Newborn: Severe obesity ; Obesity, Morbid - complications ; Obesity, Morbid - surgery ; Pregnancy ; Pregnancy Complications - surgery ; Prospective Studies ; Risk Factors ; Surgery ; Trace element ; Vitamin ; Young Adult</subject><ispartof>Surgery for obesity and related diseases, 2017-08, Vol.13 (8), p.1384-1391</ispartof><rights>2017 American Society for Bariatric Surgery</rights><rights>Copyright © 2017 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-5527184f4bf396945ac9bbc93e7f2203878b30defe656e618a32147832e64aa33</citedby><cites>FETCH-LOGICAL-c459t-5527184f4bf396945ac9bbc93e7f2203878b30defe656e618a32147832e64aa33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S155072891730148X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28526433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gascoin, Geraldine, M.D., Ph.D</creatorcontrib><creatorcontrib>Gerard, Maxime, M.D</creatorcontrib><creatorcontrib>Sallé, Agnès, M.D., Ph.D</creatorcontrib><creatorcontrib>Becouarn, Guillaume, M.D</creatorcontrib><creatorcontrib>Rouleau, Stephanie, M.D</creatorcontrib><creatorcontrib>Sentilhes, Loïc, M.D., Ph.D</creatorcontrib><creatorcontrib>Coutant, Régis, M.D</creatorcontrib><title>Risk of low birth weight and micronutrient deficiencies in neonates from mothers after gastric bypass: A case control study</title><title>Surgery for obesity and related diseases</title><addtitle>Surg Obes Relat Dis</addtitle><description>Abstract Background An increased risk of small-for-gestational-age infants after maternal bariatric surgery has been shown. The risk of micronutrients deficiencies in these neonates is unclear. Objective To screen for micronutrients deficiencies in newborns of mothers with gastric bypass Settings University Hospital in Angers, France Methods This study compared the clinical and cord blood biological characteristics of 56 newborns of mothers with prior gastric bypass (RYGB) and 56 newborns of non-obese healthy mothers after normal pregnancy (controls), followed between 01/03/2008 and 31/10/2012. Cord blood micronutrients concentrations from controls were used for establishing normative data. After RYGB, the women took daily micronutrients supplements. Results RYGB mothers lost 18.1±6.3 kg/m2 of Body Mass Index (BMI) in the 11-69 months between surgery and pregnancy onset (percentage of excess weight loss 79±20%), reaching BMI of 30.1±6.0 kg/m2 compared with 22.3±4.0 kg/m2 in the controls (p<0.05). Neonates born to RYGB mothers were small-for-gestational-age in 23% of cases vs. 3.6% in the control group (p<0.01). A higher percentage of RYGB neonates had cord blood concentrations below the 2.5th percentile for calcium (19% vs 2%), zinc (13% vs 3%,), iron (19% vs 2%), and vitamin A (13% vs 3%), and over the 97.5th percentile for magnesium (13% vs 3%), vitamin E (16% vs 3%), 25-hydroxy-vitamin D (13% vs 2%), and vitamin B12 (14% vs 2%)(p<0.05 for all comparisons). Conclusion Neonates from RYGB mothers showed cord blood micronutrient differences as compared to neonates from healthy mothers. The comparison with neonates from morbidly obese women is still to be done.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bariatric</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Gastric Bypass</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age</subject><subject>Micronutrient</subject><subject>Micronutrients - deficiency</subject><subject>Middle Aged</subject><subject>Morbid obesity</subject><subject>Neonate</subject><subject>Newborn: Severe obesity</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - surgery</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - surgery</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Trace element</subject><subject>Vitamin</subject><subject>Young Adult</subject><issn>1550-7289</issn><issn>1878-7533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1rFTEUDaLYWv0FgmTpZsZ8TOZDUCilfkBBqAruQiZz05fXmckzN2N5-Oeb6Wu7cOMinLM4J_eecwl5zVnJGa_fbUsMJg6lYLwpmSwzPCHHvG3aolFSPs1cKVY0ou2OyAvELWOyVo14To5Eq0RdSXlM_l56vKbB0THc0N7HtKE34K82iZp5oJO3McxLih7mRAdw3maWH1I_0xnCbFLmLoaJTiFtICI1LkGkVwazy9J-vzOI7-kptQaB2jCnGEaKaRn2L8kzZ0aEV_d4Qn5-Ov9x9qW4-Pb569npRWEr1aVCKdHwtnJV72RXd5Uytut720lonBBM5sC9ZHk5qFUNNW-NFLxqWimgroyR8oS8Pfy7i-H3Apj05NHCOJqcYEHNO8ba1dNmqTxIc27ECE7vop9M3GvO9Nq63uq71vXaumZSZ8iuN_cDln6C4dHzUHMWfDgIIMf84yFqvCsSBh_BJj0E_58BH__x29HP3prxGvaA27DEOTeouUahmf6-Hn69e7ayHOuXvAW7n6p-</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Gascoin, Geraldine, M.D., Ph.D</creator><creator>Gerard, Maxime, M.D</creator><creator>Sallé, Agnès, M.D., Ph.D</creator><creator>Becouarn, Guillaume, M.D</creator><creator>Rouleau, Stephanie, M.D</creator><creator>Sentilhes, Loïc, M.D., Ph.D</creator><creator>Coutant, Régis, M.D</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Risk of low birth weight and micronutrient deficiencies in neonates from mothers after gastric bypass: A case control study</title><author>Gascoin, Geraldine, M.D., Ph.D ; Gerard, Maxime, M.D ; Sallé, Agnès, M.D., Ph.D ; Becouarn, Guillaume, M.D ; Rouleau, Stephanie, M.D ; Sentilhes, Loïc, M.D., Ph.D ; Coutant, Régis, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-5527184f4bf396945ac9bbc93e7f2203878b30defe656e618a32147832e64aa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bariatric</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Gastric Bypass</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age</topic><topic>Micronutrient</topic><topic>Micronutrients - deficiency</topic><topic>Middle Aged</topic><topic>Morbid obesity</topic><topic>Neonate</topic><topic>Newborn: Severe obesity</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - surgery</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - surgery</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Trace element</topic><topic>Vitamin</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gascoin, Geraldine, M.D., Ph.D</creatorcontrib><creatorcontrib>Gerard, Maxime, M.D</creatorcontrib><creatorcontrib>Sallé, Agnès, M.D., Ph.D</creatorcontrib><creatorcontrib>Becouarn, Guillaume, M.D</creatorcontrib><creatorcontrib>Rouleau, Stephanie, M.D</creatorcontrib><creatorcontrib>Sentilhes, Loïc, M.D., Ph.D</creatorcontrib><creatorcontrib>Coutant, Régis, M.D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery for obesity and related diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gascoin, Geraldine, M.D., Ph.D</au><au>Gerard, Maxime, M.D</au><au>Sallé, Agnès, M.D., Ph.D</au><au>Becouarn, Guillaume, M.D</au><au>Rouleau, Stephanie, M.D</au><au>Sentilhes, Loïc, M.D., Ph.D</au><au>Coutant, Régis, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of low birth weight and micronutrient deficiencies in neonates from mothers after gastric bypass: A case control study</atitle><jtitle>Surgery for obesity and related diseases</jtitle><addtitle>Surg Obes Relat Dis</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>13</volume><issue>8</issue><spage>1384</spage><epage>1391</epage><pages>1384-1391</pages><issn>1550-7289</issn><eissn>1878-7533</eissn><abstract>Abstract Background An increased risk of small-for-gestational-age infants after maternal bariatric surgery has been shown. The risk of micronutrients deficiencies in these neonates is unclear. Objective To screen for micronutrients deficiencies in newborns of mothers with gastric bypass Settings University Hospital in Angers, France Methods This study compared the clinical and cord blood biological characteristics of 56 newborns of mothers with prior gastric bypass (RYGB) and 56 newborns of non-obese healthy mothers after normal pregnancy (controls), followed between 01/03/2008 and 31/10/2012. Cord blood micronutrients concentrations from controls were used for establishing normative data. After RYGB, the women took daily micronutrients supplements. Results RYGB mothers lost 18.1±6.3 kg/m2 of Body Mass Index (BMI) in the 11-69 months between surgery and pregnancy onset (percentage of excess weight loss 79±20%), reaching BMI of 30.1±6.0 kg/m2 compared with 22.3±4.0 kg/m2 in the controls (p<0.05). Neonates born to RYGB mothers were small-for-gestational-age in 23% of cases vs. 3.6% in the control group (p<0.01). A higher percentage of RYGB neonates had cord blood concentrations below the 2.5th percentile for calcium (19% vs 2%), zinc (13% vs 3%,), iron (19% vs 2%), and vitamin A (13% vs 3%), and over the 97.5th percentile for magnesium (13% vs 3%), vitamin E (16% vs 3%), 25-hydroxy-vitamin D (13% vs 2%), and vitamin B12 (14% vs 2%)(p<0.05 for all comparisons). Conclusion Neonates from RYGB mothers showed cord blood micronutrient differences as compared to neonates from healthy mothers. The comparison with neonates from morbidly obese women is still to be done.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28526433</pmid><doi>10.1016/j.soard.2017.03.017</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Bariatric Case-Control Studies Female Fetal Blood - chemistry Gastric Bypass Gastroenterology and Hepatology Humans Infant, Newborn Infant, Small for Gestational Age Micronutrient Micronutrients - deficiency Middle Aged Morbid obesity Neonate Newborn: Severe obesity Obesity, Morbid - complications Obesity, Morbid - surgery Pregnancy Pregnancy Complications - surgery Prospective Studies Risk Factors Surgery Trace element Vitamin Young Adult |
| title | Risk of low birth weight and micronutrient deficiencies in neonates from mothers after gastric bypass: A case control study |
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