LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway

LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway

Highlights • LncRNA GAS5 plays a key role in CFs activation and fibrosis. • GAS5/miR-21/PTEN axis involvement in CFs activation. • GAS5 negative controls miR-21 expression in activated CFs.

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Veröffentlicht in:Toxicology (Amsterdam) 2017-07, Vol.386, p.11-18
Hauptverfasser: Tao, Hui, Zhang, Jia-Gui, Qin, Run-He, Dai, Chen, Shi, Peng, Yang, Jing-Jing, Deng, Zi-Yu, Shi, Kai-Hu
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cardiac fibroblasts
Cardiac fibrosis
Emergency
Fibroblasts - metabolism
Fibrosis - pathology
LncRNA GAS5
Male
Matrix Metalloproteinase 2 - metabolism
MicroRNAs - genetics
miR-21
PTEN Phosphohydrolase - genetics
Rats
Rats, Sprague-Dawley
RNA, Long Noncoding - genetics
RNA, Small Nucleolar - genetics
Signal Transduction - genetics
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Beschreibung
Zusammenfassung:Highlights • LncRNA GAS5 plays a key role in CFs activation and fibrosis. • GAS5/miR-21/PTEN axis involvement in CFs activation. • GAS5 negative controls miR-21 expression in activated CFs.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2017.05.007