STAT5 alters the state of transcriptional networks, driving aggressive leukemia

STAT5 alters the state of transcriptional networks, driving aggressive leukemia

The transcription factor STAT5 acts as an oncoprotein in B cell acute lymphoblastic leukemia, competing with the transcription factors NF-κB and Ikaros for binding to DNA.

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Bibliographische Detailangaben
Veröffentlicht in:Nature immunology 2017-06, Vol.18 (6), p.597-598
Hauptverfasser: Dovat, Sinisa, Payne, Kimberly J
Format: Artikel
Sprache:eng
Schlagworte:
631/250/2502
692/699/67/1990/283
Acute lymphocytic leukemia
Biomedical and Life Sciences
Biomedicine
Care and treatment
Development and progression
Gene expression
Genetic aspects
Health aspects
Immunology
Infectious Diseases
Leukemia
news-and-views
STAT5
Stat5 protein
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Beschreibung
Zusammenfassung:The transcription factor STAT5 acts as an oncoprotein in B cell acute lymphoblastic leukemia, competing with the transcription factors NF-κB and Ikaros for binding to DNA.
ISSN:1529-2908
1529-2916
DOI:10.1038/ni.3747