In vivo and molecular docking studies using whole extract and phytocompounds of Aegle marmelos fruit protective effects against Isoproterenol-induced Myocardial infarction in rats

Highlights • Oxidative stress produced by the excess generation of ROS plays a key role in the development of MI. • AMFE acts as a strong protective agent against ISO-induced MI. • AMFE showed strong antioxidant activity and hypolipidemic properties. • Total phenolic compounds present in AMFE are re...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-07, Vol.91, p.880-889
Hauptverfasser:	Krushna, Gadamsetty Saayi, Shivaranjani, Vutharadhi Leela, Umamaheswari, Jolapuram, Srinivasulu, Cheemanapalli, Hussain, Shaik Althaf, Kareem, Mohammed Abdul, Reddy, Vaddi Damodara, Ali, Daoud, Lokhande, Kiran Bharat, Swamy, K. Venkateswara, Kodidhela, Lakshmi Devi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aegle - chemistry Aegle marmelos Animals Cardiotonic Agents - chemistry Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Fruit - chemistry Internal Medicine Isoproterenol Lipid profile Male Medical Education Molecular docking Molecular Docking Simulation Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - chemically induced Myocardial Infarction - drug therapy Myocardial Infarction - enzymology Phytochemicals - chemistry Phytochemicals - pharmacology Phytochemicals - therapeutic use Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats, Wistar
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Beschreibung
Zusammenfassung:	Highlights • Oxidative stress produced by the excess generation of ROS plays a key role in the development of MI. • AMFE acts as a strong protective agent against ISO-induced MI. • AMFE showed strong antioxidant activity and hypolipidemic properties. • Total phenolic compounds present in AMFE are responsible for this protective action. • Further, molecular docking studies confirmed protective effects of AMFE.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2017.04.115