Re-evaluation of routine dengue virus serology in travelers in the era of Zika virus emergence

Highlights • 100% specificity of the DENV NS1 antigen ELISA in ZIKV RNA positive blood samples. • A high cross-reactivity of DENV IgM and IgG in ZIKV confirmed patient sera. • The high rate of previous DENV exposure in travelers complicates serology

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical virology 2017-07, Vol.92, p.25-31
Hauptverfasser:	van Meer, Maurits P.A, Mögling, Ramona, Klaasse, Janienne, Chandler, Felicity D, Pas, Suzan D, van der Eijk, Annemiek A, Koopmans, Marion P.G, Reusken, Chantal B.E.M, GeurtsvanKessel, Corine H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Antibodies, Viral - blood Cohort Studies Cross Reactions Dengue - diagnosis Dengue - virology Dengue Virus - genetics Dengue Virus - immunology Dengue Virus - isolation & purification Enzyme-Linked Immunosorbent Assay - methods Female Humans Immunoglobulin G - blood Immunoglobulin M - blood Infectious Disease Male Middle Aged Netherlands Real-Time Polymerase Chain Reaction RNA, Viral - blood Serologic Tests Suriname Travel-Related Illness Viral Nonstructural Proteins - blood Viral Nonstructural Proteins - immunology Zika Virus - genetics Zika Virus - immunology Zika Virus - isolation & purification Zika Virus Infection - diagnosis Zika Virus Infection - virology
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Beschreibung
Zusammenfassung:	Highlights • 100% specificity of the DENV NS1 antigen ELISA in ZIKV RNA positive blood samples. • A high cross-reactivity of DENV IgM and IgG in ZIKV confirmed patient sera. • The high rate of previous DENV exposure in travelers complicates serology
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2017.05.001