Nocturia and Prevalence of Depressive Symptoms in Japanese Adult Patients With Type 2 Diabetes Mellitus: The Dogo Study

No studies have investigated the association between nocturia and depressive symptoms in patients with type 2 diabetes mellitus. Because nocturia and depressive symptoms are common in patients with type 2 diabetes, we examined this association in Japanese patients with type 2 diabetes. We studied 762 Japanese patients with type 2 diabetes. A self-administered questionnaire was used to collect information about the variables under study. The subjects were divided into 3 groups according to their nocturnal micturition: 1) no nocturia; 2) mild nocturia (1 void per night) and 3) moderate to severe nocturia (2 or more voids per night). Depressive symptoms were defined as being present when a subject had a Self-Rating Depression Scale score higher than 49. The prevalence values of mild nocturia, moderate to severe nocturia and depressive symptoms were 39.5%, 41.9% and 16.8%, respectively. Both mild nocturia and moderate to severe nocturia were independently positively associated with depressive symptoms in all patients; the adjusted ORs were 1.96 (95% CI 1.06 to 3.77) and 2.58 (95% CI 1.38 to 5.04). In female patients, both mild nocturia and moderate to severe nocturia were independently associated with depressive symptoms; the adjusted ORs were 5.26 (95% CI 1.73 to 20.61) and 6.91 (95% CI 2.15 to 28.54), respectively. In male patients, neither mild nocturia nor moderate to severe nocturia was significantly related to depressive symptoms. In Japanese female patients with type 2 diabetes, nocturia may be positively associated with depressive symptoms. Aucune étude n'a abordé l'association entre la nycturie et les symptômes dépressifs chez les patients atteints de diabète de type 2. Étant donné que la nycturie et les symptômes dépressifs sont courants chez les patients atteints de diabète de type 2, nous avons examiné cette association chez des patients japonais présentant ce type de diabète. Nous avons mené une étude portant sur 762 patients japonais atteints de diabète de type 2. Un questionnaire autoadministré a servi à recueillir des renseignements sur les variables à l'étude. Les patients ont été divisés en 3 groupes en fonction des critères suivants : 1) absence de nycturie; 2) nycturielégère (1 miction par nuit); 3) nycturie modérée ou marquée (2 mictions ou plus par nuit). Les symptômes dépressifs étaient réputés présents lorsqu'un patient obtenait un score supérieur à 49 sur l'échelle d'autoévaluation de la dépression. La prévalence de la nycturie légère,