Hyperoside protects against chronic mild stress-induced learning and memory deficits

Highlights • Hyperoside enhances learning and memory in CMS rats. • The protective mechanism of hyperoside might be related to the regulation of BDNF. • Hyperoside-enriched diets may contribute to prevent and treat stress-related diseases.

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Bibliographische Detailangaben
Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-07, Vol.91, p.831-840
Hauptverfasser:	Gong, Yeli, Yang, Youhua, Chen, Xiaoqing, Yang, Min, Huang, Dan, Yang, Rong, Zhou, Lianying, Li, Changlei, Xiong, Qiuju, Xiong, Zhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BDNF Brain-Derived Neurotrophic Factor - metabolism Carbazoles - pharmacology Chronic Disease Chronic mild stress Cognition - drug effects Corticosterone - blood Depression - blood Depression - complications Depression - drug therapy Depression - physiopathology Hippocampus - metabolism Hyperoside Indole Alkaloids - pharmacology Internal Medicine Learning - drug effects Learning and memory Male Maze Learning - drug effects Medical Education Memory Disorders - blood Memory Disorders - drug therapy Memory Disorders - etiology Memory Disorders - physiopathology Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Quercetin - analogs & derivatives Quercetin - chemistry Quercetin - pharmacology Quercetin - therapeutic use Rats, Sprague-Dawley Receptor, trkB - metabolism Stress, Psychological - blood Stress, Psychological - complications Stress, Psychological - physiopathology
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Beschreibung
Zusammenfassung:	Highlights • Hyperoside enhances learning and memory in CMS rats. • The protective mechanism of hyperoside might be related to the regulation of BDNF. • Hyperoside-enriched diets may contribute to prevent and treat stress-related diseases.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2017.05.019