Control of astrocyte morphology by Rho GTPases

Control of astrocyte morphology by Rho GTPases

Highlights • Small Rho GTPases impact astrocyte morphology. • FRET-based biosensors are useful tools to monitor small GTPase activity in living cells. • By activating RhoA, Rac1 or Cdc42, morphology of astrocytes can be modulated.

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Bibliographische Detailangaben
Veröffentlicht in:Brain research bulletin 2018-01, Vol.136, p.44-53
Hauptverfasser: Zeug, Andre, Müller, Franziska E, Anders, Stefanie, Herde, Michel K, Minge, Daniel, Ponimaskin, Evgeni, Henneberger, Christian
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Astrocytes - cytology
Astrocytes - enzymology
Humans
Neurology
rho GTP-Binding Proteins - metabolism
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Zusammenfassung:Highlights • Small Rho GTPases impact astrocyte morphology. • FRET-based biosensors are useful tools to monitor small GTPase activity in living cells. • By activating RhoA, Rac1 or Cdc42, morphology of astrocytes can be modulated.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2017.05.003