Mucoepidermoid Carcinoma Post-Radioactive Iodine Treatment for Papillary Thyroid Carcinoma: Unique presentation and putative etiologic association

We report the development of mucoepidermoid carcinomas (MEC) of the parotid gland in two adult patients after a relatively short duration of radioactive iodine (RAI) treatment for papillary thyroid carcinoma (PTC). Both instances, together with those previously reported, underscore the selective nat...

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Veröffentlicht in:	Human pathology 2017-10, Vol.68, p.189-192
Hauptverfasser:	Saluja, Karan, MD, Butler, Randall T, MD, Pytynia, Kristen B., MD, Zhao, Bihong, MD, PhD, Karni, Ron J., MD, Weber, Randal S., MD, El-Naggar, Adel K., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Biopsy Cancer therapies Carcinoma, Mucoepidermoid - etiology Carcinoma, Mucoepidermoid - genetics Carcinoma, Mucoepidermoid - pathology Carcinoma, Mucoepidermoid - surgery Carcinoma, Papillary - pathology Carcinoma, Papillary - radiotherapy Chromosomes Chromosomes, Human - genetics Cytogenetic Analysis Female Humans Iodine Iodine Radioisotopes - adverse effects Lymphatic system Male Medical imaging Metastasis Middle Aged Mucoepidermoid carcinoma Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - pathology Neoplasms, Radiation-Induced - surgery Oral cancer Papillary thyroid carcinoma Parotid Neoplasms - etiology Parotid Neoplasms - genetics Parotid Neoplasms - pathology Parotid Neoplasms - surgery Pathology Patients Radioactive iodine treatment Radiopharmaceuticals - adverse effects Risk Factors Salivary gland carcinoma Secondary carcinoma Thyroid cancer Thyroid Cancer, Papillary Thyroid Neoplasms - pathology Thyroid Neoplasms - radiotherapy Tumors
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Beschreibung
Zusammenfassung:	We report the development of mucoepidermoid carcinomas (MEC) of the parotid gland in two adult patients after a relatively short duration of radioactive iodine (RAI) treatment for papillary thyroid carcinoma (PTC). Both instances, together with those previously reported, underscore the selective nature of the MEC phenotype development in patients with PTC as a consequence of RAI treatment. Efforts to alleviate salivary pathophysiologic damage by RAI in these patients are warranted.
ISSN:	0046-8177 1532-8392
DOI:	10.1016/j.humpath.2017.04.019