What factors determine treatment outcome in aneurysmal subarachnoid haemorrhage in the modern era? – a post hoc STASH analysis

Abstract Introduction The management of aneurysmal SAH has changed dramatically in the last few decades with the publication of a few major studies including The International Cooperative Study on the Timing of Aneurysm Surgery Study, International Subarachnoid Aneurysm Trial (ISAT). The aim of this study is to analyse the outcome of patients with aSAH based on a contemporary series, identify the risk factors for poor outcome, and focusing on patients with good grades aSAH (to match the ISAT cohort). Method Baseline demographic and outcome data (mRS) was available on the 803 patients recruited from the STASH (Simvastatin in aneurysmal subarachnoid haemorrhage) trial for post hoc analysis, using chi square test or two-sample t-test. Logistic regression analysis was performed to assess the risk factors for poor outcome at 6 months. Propensity matched analysis comparing coiling and clipping, and subgroup analysis of good grades patients (WFNS I-II) were also performed. Result Logistic regression analysis showed that the treatment modality (i.e coiling or clipping) was not associated with poor outcome at 6 months (p=0.839). The risk factors associated with poor outcome at 6 months were poor admission WFNS grade (p