Molecular Typing of Syphilis-Causing Strains Among Human Immunodeficiency Virus-Positive Patients in Antwerp, Belgium

Centers for Disease Control and Prevention and sequencingbased treponeme typing was used to analyze 72 blood samples, collected from human immunodeficiency virus and syphilis co-infected patients during 2014 to 2015 in Antwerp, Belgium. Twenty-nine (40.3%) isolates were polymerase chain reaction pos...

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Veröffentlicht in:	Sexually transmitted diseases 2017-06, Vol.44 (6), p.376-379
Hauptverfasser:	Mikalová, Lenka, Grillová, Linda, Osbak, Kara, Strouhal, Michal, Kenyon, Chris, Crucitti, Tania, Šmajs, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - pharmacology Belgium - epidemiology Blood tests Chemical analysis Disease control Drug Resistance, Bacterial - genetics Female Genotype Genotypes HIV HIV Seropositivity - complications HIV Seropositivity - epidemiology HIV Seropositivity - microbiology Human immunodeficiency virus Humans Keyboarding Macrolides - pharmacology Male Middle Aged Molecular Typing Molecules Patients Point Mutation Polymerase chain reaction Polymorphism, Restriction Fragment Length Prevention RNA, Ribosomal, 23S - genetics Sexually transmitted diseases STD Subtypes Syphilis Syphilis - complications Syphilis - drug therapy Syphilis - epidemiology Syphilis - microbiology Treponema pallidum - classification Treponema pallidum - genetics Treponema pallidum - isolation & purification Viruses
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Zusammenfassung:	Centers for Disease Control and Prevention and sequencingbased treponeme typing was used to analyze 72 blood samples, collected from human immunodeficiency virus and syphilis co-infected patients during 2014 to 2015 in Antwerp, Belgium. Twenty-nine (40.3%) isolates were polymerase chain reaction positive for Treponema pallidum, and all tested were macrolide-resistant. Four genotypes were identified by sequencing-based typing including two new genotypes, U4NR8 and SU9R8, whereas enhanced Centers for Disease Control and Prevention typing revealed 7 subtypes.
ISSN:	0148-5717 1537-4521
DOI:	10.1097/olq.0000000000000600