IL-6 promotes epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 signaling pathway

Long-term peritoneal dialysis (PD) therapy results in functional and structural alteration of the peritoneal membrane, including epithelial-to-mesenchymal transition (EMT). Interleukin 6 (IL-6) is a local pleiotropic cytokine, hypothesized to play an important role in EMT. This study was designed to...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2017-08, Vol.313 (2), p.F310-F318
Hauptverfasser:	Xiao, Jing, Gong, Yanan, Chen, Ying, Yu, Dahai, Wang, Xiaoyang, Zhang, Xiaoxue, Dou, Yanna, Liu, Dong, Cheng, Genyang, Lu, Shan, Yuan, Wenming, Li, Yansheng, Zhao, Zhanzheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Adult Cadherins - metabolism Cell Shape Cell Survival Cells Cells, Cultured Dialysis Solutions - metabolism Dose-Response Relationship, Drug E-cadherin Epithelial-Mesenchymal Transition - drug effects Female Genotype & phenotype Hemodialysis Humans Interleukin 6 Interleukin-6 - blood Interleukin-6 - toxicity Janus kinase 2 Janus Kinase 2 - metabolism Kidney Failure, Chronic - blood Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - therapy Male Membranes Mesenchyme Middle Aged Peritoneal dialysis Peritoneal Dialysis - adverse effects Peritoneum Peritoneum - drug effects Peritoneum - enzymology Peritoneum - pathology Phenotype Preservation Signal transduction Signal Transduction - drug effects Smooth muscle Stat3 protein STAT3 Transcription Factor - metabolism Structure-function relationships Time Factors Ultrafiltration Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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