Obesity and breast cancer: role of inflammation and aromatase

Obesity is now recognised to be an inflammatory condition in which dysregulated metabolism plays an integral role. Inflammatory mediators regulate aromatase expression in the human breast as one mechanism whereby they increase the risk of breast cancer, especially in women who are obese.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular endocrinology 2013-12, Vol.51 (3), p.T51-T59
Hauptverfasser:	Simpson, Evan R, Brown, Kristy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatase - genetics Aromatase - metabolism Breast Neoplasms - enzymology Breast Neoplasms - immunology Female Humans Inflammation - enzymology Inflammation - immunology Obesity - enzymology Obesity - immunology Thematic Review
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Beschreibung
Zusammenfassung:	Obesity is now recognised to be an inflammatory condition in which dysregulated metabolism plays an integral role. Inflammatory mediators regulate aromatase expression in the human breast as one mechanism whereby they increase the risk of breast cancer, especially in women who are obese.
ISSN:	0952-5041 1479-6813
DOI:	10.1530/JME-13-0217