Loss of CADM4 expression is associated with poor prognosis in small intestinal adenocarcinomas

We evaluated the association of cell adhesion molecule 4 (CADM4) expression with clinicopathologic parameters and overall survival (OS) in patients with small intestinal adenocarcinomas (SIAs) and determined its prognostic significance. CADM4 immunohistochemical staining was performed for 170 SIA sa...

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Veröffentlicht in:	APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2017-05, Vol.125 (5), p.437-443
Hauptverfasser:	Kim, Kyung‐Ju, Kim, Jung Yeon, Hong, Seung‐Mo, Gu, Mi Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - pathology adenocarcinoma, prognosis Adult Aged Aged, 80 and over CADM4 Cell Adhesion Molecules - analysis Female Humans Immunoglobulins - analysis Immunohistochemistry Intestinal Neoplasms - diagnosis Intestinal Neoplasms - pathology Intestine, Small - pathology Male Middle Aged Prognosis small intestine Survival Analysis Young Adult
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Zusammenfassung:	We evaluated the association of cell adhesion molecule 4 (CADM4) expression with clinicopathologic parameters and overall survival (OS) in patients with small intestinal adenocarcinomas (SIAs) and determined its prognostic significance. CADM4 immunohistochemical staining was performed for 170 SIA samples. Loss of or low CADM4 expression was observed in 26 (15.3%) and 50 (29.4%) cases, respectively, and it was significantly associated with undifferentiated histology (p
ISSN:	0903-4641 1600-0463
DOI:	10.1111/apm.12684