Supplementation of highly concentrated [beta]-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women

Background Serum [beta]-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum [beta]-cryptoxanthin levels in them were relatively lower than normal subjects. Objective We hypothesize that supplementation of highly concentrated [beta]-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between [beta]-cryptoxanthin intake and serum adipocytokine levels. Methods An intervention study consisted of a 3-week long before-and-after controlled trial, where [beta]-cryptoxanthin (4.7 mg/day) was given to 17 moderately obese postmenopausal women. Results The results indicated no significant changes in body weight or body mass index (BMI). Serum [beta]-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased. Conclusions We concluded that increasing the intake of [beta]-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome. Keywords: [beta]-cryptoxanthin supplementation, Serum HMW-adiponectin, Serum PAI-1, Intervention study, Satsuma mandarin