Engineering fatty acid synthases for directed polyketide production

In vitro and in silico analysis enables the rational design of fatty acid synthase (FAS)-mediated pathways for the compartmentalized production of desirable fatty acids and a polyketide lactone. In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids a...

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Veröffentlicht in:	Nature chemical biology 2017-04, Vol.13 (4), p.363-365
Hauptverfasser:	Gajewski, Jan, Buelens, Floris, Serdjukow, Sascha, Janßen, Melanie, Cortina, Niña, Grubmüller, Helmut, Grininger, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2390 631/326/252/318 631/92/60 631/92/607 82 82/80 82/83 Biochemical Engineering Biochemistry Bioorganic Chemistry Biosynthesis brief-communication Cell Biology Chemical synthesis Chemistry Chemistry/Food Science Corynebacterium - enzymology Fatty Acid Synthases - chemistry Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty acids Metabolites Models, Molecular Molecular Structure Polyketides - chemistry Polyketides - metabolism Protein Engineering
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