Effects of Long‐Term Etanercept Treatment on Clinical Outcomes and Objective Signs of Inflammation in Early Nonradiographic Axial Spondyloarthritis: 104‐Week Results From a Randomized, Placebo‐Controlled Study

Objective To evaluate the long‐term clinical and imaging efficacy of etanercept in patients with early, active nonradiographic axial spondyloarthritis (SpA). Methods Adult patients who satisfied the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial SpA (b...

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Veröffentlicht in:	Arthritis care & research (2010) 2017-10, Vol.69 (10), p.1590-1598
Hauptverfasser:	Dougados, Maxime, van der Heijde, Désirée, Sieper, Joachim, Braun, Jürgen, Citera, Gustavo, Lenaerts, Jan, van den Bosch, Filip, Wei, James Cheng‐Chung, Pedersen, Ron, Bonin, Randi, Jones, Heather, Marshall, Lisa, Logeart, Isabelle, Vlahos, Bonnie, Bukowski, Jack F., Maksymowych, Walter P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Ankylosing spondylitis Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antirheumatic Agents - administration & dosage Antirheumatic Agents - adverse effects Arthritis Biological Products - administration & dosage Biological Products - adverse effects C-reactive protein Clinical outcomes Clinical trials Disability Evaluation Double-Blind Method Drug Substitution Etanercept Etanercept - administration & dosage Etanercept - adverse effects Female Humans Inflammatory diseases Magnetic Resonance Imaging Male NMR Nonsteroidal anti-inflammatory drugs Nuclear magnetic resonance Remission Induction Rheumatic diseases Spine - diagnostic imaging Spine - drug effects Spine - immunology Spondylarthritis - diagnostic imaging Spondylarthritis - drug therapy Spondylarthritis - immunology Spondylitis Time Factors Treatment Outcome Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology
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Zusammenfassung:	Objective To evaluate the long‐term clinical and imaging efficacy of etanercept in patients with early, active nonradiographic axial spondyloarthritis (SpA). Methods Adult patients who satisfied the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial SpA (but not the modified New York radiographic criteria), with symptom duration >3 months to
ISSN:	2151-464X 2151-4658
DOI:	10.1002/acr.23276