The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix

Extracellular matrix (ECM) stiffness regulates cell differentiation, survival, and migration. Our previous study has shown that the interaction of the focal adhesion protein vinculin with vinexin α plays a critical role in sensing ECM stiffness and regulating stiffness-dependent cell migration. Howe...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2017-06, Vol.81 (6), p.1136-1147
Hauptverfasser:	Nagasato, Ayaka Ichikawa, Yamashita, Hiroshi, Matsuo, Michinori, Ueda, Kazumitsu, Kioka, Noriyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Cyclodextrins - pharmacology Biomechanical Phenomena Caveolin 1 - genetics Caveolin 1 - metabolism Cell Adhesion - drug effects Cell Line Cell Movement - drug effects Embryo, Mammalian extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix - ultrastructure Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - ultrastructure focal adhesions Focal Adhesions - drug effects Focal Adhesions - metabolism Focal Adhesions - ultrastructure Gene Expression Regulation Hardness lipid raft mechanotransduction Membrane Microdomains - drug effects Membrane Microdomains - metabolism Membrane Microdomains - ultrastructure Membrane Proteins - genetics Membrane Proteins - metabolism Mice Muscle Proteins - genetics Muscle Proteins - metabolism Paxillin - genetics Paxillin - metabolism Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Signal Transduction vinculin Vinculin - genetics Vinculin - metabolism
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