Evaluation of the surface chemistry and drug-polymer interaction of semi-crystalline micro-particles for the development of controlled release formulations

Evaluation of the surface chemistry and drug-polymer interaction of semi-crystalline micro-particles for the development of controlled release formulations

This research work explores the surface chemistry and drug-polymer interaction in the manufactured controlled release micro-particles. Isoniazid (INH) was used as a model anti-tubercular drug while Eudragit® S100 (S100), Eudragit® L100-55 based co-processed Acryl EZE (EZE) and Ethylcellulose ECN10 (...

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Veröffentlicht in:Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems Biomimetic Materials, Sensors and Systems, 2017-07, Vol.76, p.559-567
Hauptverfasser: Mithu, Sadeque H, Haque, Syed N, Chowdhry, Babur Z, Nokhodchi, Ali, Maniruzzaman, Mohammed
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatibility
Carboxyl group
Chemistry, Pharmaceutical
Controlled release
Delayed-Action Preparations
Desiccation
Dosage
Drying
Ethyl cellulose
Formulations
Isoniazid
Materials science
Particle Size
Particulates
pH effects
Polymers
Solid state
Solubility
Spray drying
Surface analysis (chemical)
Surface chemistry
Surface Properties
X ray photoelectron spectroscopy
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Zusammenfassung:This research work explores the surface chemistry and drug-polymer interaction in the manufactured controlled release micro-particles. Isoniazid (INH) was used as a model anti-tubercular drug while Eudragit® S100 (S100), Eudragit® L100-55 based co-processed Acryl EZE (EZE) and Ethylcellulose ECN10 (ECN10) were used as polymeric carriers. INH containing micro-particles were prepared using a mini spray dryer B-290 (Buchi, Switzerland). The drug polymer ratios were optimized at 1:1 and 1:3 to evaluate the effect of polymers on the release of the drug from the micro-particles. Solid state characterization via SEM and particle size analysis of the manufactured micro-particles showed densely aggregated spherical particles with a mean diameter
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2017.03.154