Iridium-Catalyzed Direct Regioselective C4-Amidation of Indoles under Mild Conditions

Iridium-Catalyzed Direct Regioselective C4-Amidation of Indoles under Mild Conditions

An efficient Ir-catalyzed amidation of indoles with sulfonyl azides is disclosed, affording diverse C4-amidated indoles exclusively under mild conditions. In this protocol, a variety of indoles with commonly occurring functional groups such as formyl, acetyl, carboxyl, amide, and ester at the C3 pos...

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Veröffentlicht in:Organic letters 2017-05, Vol.19 (10), p.2502-2505
Hauptverfasser: Chen, Shuyou, Feng, Boya, Zheng, Xuesong, Yin, Jiangliang, Yang, Shiping, You, Jingsong
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient Ir-catalyzed amidation of indoles with sulfonyl azides is disclosed, affording diverse C4-amidated indoles exclusively under mild conditions. In this protocol, a variety of indoles with commonly occurring functional groups such as formyl, acetyl, carboxyl, amide, and ester at the C3 position are well tolerated.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b00730