Keep Them Close: PRC2 Poises Enhancer-Promoter Interactions at Anterior Neuronal Genes

Enhancers exist in different epigenetic states: active, primed, or poised. However, it is not yet understood how the different enhancer states influence gene activation. In this issue of Cell Stem Cell, Cruz-Molina et al. (2017) unravel how poised enhancers activate anterior neural genes and the rol...

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Veröffentlicht in:	Cell stem cell 2017-05, Vol.20 (5), p.573-575
Hauptverfasser:	Caglio, Giulia, Torlai Triglia, Elena, Pombo, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enhancer Elements, Genetic - genetics Epigenesis, Genetic - genetics Humans Mice Models, Theoretical Neurons - metabolism Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Promoter Regions, Genetic - genetics
Online-Zugang:	Volltext
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Zusammenfassung:	Enhancers exist in different epigenetic states: active, primed, or poised. However, it is not yet understood how the different enhancer states influence gene activation. In this issue of Cell Stem Cell, Cruz-Molina et al. (2017) unravel how poised enhancers activate anterior neural genes and the role of Polycomb proteins in enhancer-promoter contacts. Enhancers exist in different epigenetic states: active, primed, or poised. However, it is not yet understood how the different enhancer states influence gene activation. In this issue of Cell Stem Cell, Cruz-Molina et al. (2017) unravel how poised enhancers activate anterior neural genes and the role of Polycomb proteins in enhancer-promoter contacts.
ISSN:	1934-5909 1875-9777
DOI:	10.1016/j.stem.2017.04.006