New polymorphisms of Xeroderma Pigmentosum DNA repair genes in myelodysplastic syndrome

Highlights • New functional polymorphisms of Xeroderma Pigmentosum (XP) genes in MDS are proposed. • Polymorphic variations of XP genes are associated with several cytopenias in MDS. • XP polymorphisms alter the mRNA expression of the DNA repair genes in MDS. • XP functional polymorphisms are probab...

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Veröffentlicht in:	Leukemia research 2017-07, Vol.58, p.73-82
Hauptverfasser:	Santiago, Sabrina Pinheiro, Junior, Howard Lopes Ribeiro, de Sousa, Juliana Cordeiro, de Paula Borges, Daniela, de Oliveira, Roberta Taiane Germano, Farias, Izabelle Rocha, Costa, Marília Braga, Maia, Allan Rodrigo Soares, da Nóbrega Ito, Mayumi, Magalhães, Silvia Maria Meira, Pinheiro, Ronald Feitosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Allelic discrimination DNA Repair - genetics DNA repair genes DNA-Binding Proteins - genetics Female Functional polymorphisms Gene expression Genetic Predisposition to Disease - genetics Genotype Hematology, Oncology and Palliative Medicine Humans Male MDS Middle Aged Myelodysplastic syndrome Myelodysplastic Syndromes - genetics Polymorphism, Single Nucleotide Real-Time Polymerase Chain Reaction Xeroderma Pigmentosum Xeroderma Pigmentosum Group A Protein - genetics Xeroderma Pigmentosum Group D Protein - genetics
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Zusammenfassung:	Highlights • New functional polymorphisms of Xeroderma Pigmentosum (XP) genes in MDS are proposed. • Polymorphic variations of XP genes are associated with several cytopenias in MDS. • XP polymorphisms alter the mRNA expression of the DNA repair genes in MDS. • XP functional polymorphisms are probably related to MDS pathogenesis and prognosis.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2017.03.012