The impact of endotoxin on jejunal tissue oxygenation
Objective We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs. Methods Jejunal mucosal tissue PO2 was measured employing Clark‐type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflect...
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| Veröffentlicht in: | Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2017-08, Vol.24 (6), p.n/a |
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| container_title | Microcirculation (New York, N.Y. 1994) |
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| creator | Pajk, Werner Stadlbauer, Karl‐Heinz Kleinsasser, Axel Kotzinger, Oskar Ulmer, Hanno Hasibeder, Walter Knotzer, Hans |
| description | Objective
We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs.
Methods
Jejunal mucosal tissue PO2 was measured employing Clark‐type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated. Systemic hemodynamic variables, mesenteric venous and systemic acid base and blood gas variables, and lactate measurements were recorded. Measurements were taken at BL and after Escherichia coli LPS administration in 20 minutes intervals for 110 minutes.
Results
ETX infusion led to a significant (P |
| doi_str_mv | 10.1111/micc.12379 |
| format | Article |
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We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs.
Methods
Jejunal mucosal tissue PO2 was measured employing Clark‐type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated. Systemic hemodynamic variables, mesenteric venous and systemic acid base and blood gas variables, and lactate measurements were recorded. Measurements were taken at BL and after Escherichia coli LPS administration in 20 minutes intervals for 110 minutes.
Results
ETX infusion led to a significant (P<.05) decrease of PO2muc (from 24±4 to 8±4 mm Hg) and microvascular HbO2 (from 41±13 to 24±12%). Microcirculatory conductivity increased in ETX animals, microvascular blood flow remained unchanged (PU; from 228±45 to 232±58). ETX induced an increase in oscillation frequency of mucosal tissue oxygenation.
Conclusions
Endotoxinemia resulted in a significant depression of mucosal tissue oxygenation despite a constant microcirculatory blood flow. This impairment of tissue oxygenation resulted in an increase in the vasomotion pattern in a futile attempt to counteract the undersupply of oxygen to the jejunal tissue.</description><identifier>ISSN: 1073-9688</identifier><identifier>EISSN: 1549-8719</identifier><identifier>DOI: 10.1111/micc.12379</identifier><identifier>PMID: 28477419</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Circulatory system ; clark‐type surface oxygen electrodes ; Endotoxins - pharmacology ; Intestinal Mucosa - metabolism ; Jejunum - blood supply ; Jejunum - metabolism ; Microcirculation ; microcirculatory flowmotion ; mucosal oxygen tension ; Oxygen - metabolism ; Regional Blood Flow ; sepsis ; Swine ; vasomotion</subject><ispartof>Microcirculation (New York, N.Y. 1994), 2017-08, Vol.24 (6), p.n/a</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3579-b8489bae28fc53987db7d7553e30a7e7157b24c1fc2b3d921ba19a53ec960b8b3</citedby><cites>FETCH-LOGICAL-c3579-b8489bae28fc53987db7d7553e30a7e7157b24c1fc2b3d921ba19a53ec960b8b3</cites><orcidid>0000-0003-0132-9994</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmicc.12379$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmicc.12379$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28477419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pajk, Werner</creatorcontrib><creatorcontrib>Stadlbauer, Karl‐Heinz</creatorcontrib><creatorcontrib>Kleinsasser, Axel</creatorcontrib><creatorcontrib>Kotzinger, Oskar</creatorcontrib><creatorcontrib>Ulmer, Hanno</creatorcontrib><creatorcontrib>Hasibeder, Walter</creatorcontrib><creatorcontrib>Knotzer, Hans</creatorcontrib><title>The impact of endotoxin on jejunal tissue oxygenation</title><title>Microcirculation (New York, N.Y. 1994)</title><addtitle>Microcirculation</addtitle><description>Objective
We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs.
Methods
Jejunal mucosal tissue PO2 was measured employing Clark‐type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated. Systemic hemodynamic variables, mesenteric venous and systemic acid base and blood gas variables, and lactate measurements were recorded. Measurements were taken at BL and after Escherichia coli LPS administration in 20 minutes intervals for 110 minutes.
Results
ETX infusion led to a significant (P<.05) decrease of PO2muc (from 24±4 to 8±4 mm Hg) and microvascular HbO2 (from 41±13 to 24±12%). Microcirculatory conductivity increased in ETX animals, microvascular blood flow remained unchanged (PU; from 228±45 to 232±58). ETX induced an increase in oscillation frequency of mucosal tissue oxygenation.
Conclusions
Endotoxinemia resulted in a significant depression of mucosal tissue oxygenation despite a constant microcirculatory blood flow. This impairment of tissue oxygenation resulted in an increase in the vasomotion pattern in a futile attempt to counteract the undersupply of oxygen to the jejunal tissue.</description><subject>Animals</subject><subject>Circulatory system</subject><subject>clark‐type surface oxygen electrodes</subject><subject>Endotoxins - pharmacology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Jejunum - blood supply</subject><subject>Jejunum - metabolism</subject><subject>Microcirculation</subject><subject>microcirculatory flowmotion</subject><subject>mucosal oxygen tension</subject><subject>Oxygen - metabolism</subject><subject>Regional Blood Flow</subject><subject>sepsis</subject><subject>Swine</subject><subject>vasomotion</subject><issn>1073-9688</issn><issn>1549-8719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LwzAYB_AgitPpxQ8gBS8idOalWZKjFF8GEy_zHJI01ZS2mU2L27c3s9ODB3N5As-PPw9_AC4QnKH4bhtnzAxhwsQBOEE0EylnSBzGP2QkFXPOJ-A0hApCyDkWx2CCecZYhsQJoKt3m7hmrUyf-DKxbeF7v3Ft4tukstXQqjrpXQiDTfxm-2Zb1TvfnoGjUtXBnu_nFLw-3K_yp3T58rjI75apIZSJVPOMC60s5qWhRHBWaFYwSoklUDHLEGUaZwaVBmtSCIy0QkLFtRFzqLkmU3A95q47_zHY0MvGBWPrWrXWD0EiHiGZU84ivfpDKz908fyoBKYUzinBUd2MynQ-hM6Wct25RnVbiaDclSl3ZcrvMiO-3EcOurHFL_1pLwI0gk9X2-0_UfJ5kedj6BcobX2Y</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Pajk, Werner</creator><creator>Stadlbauer, Karl‐Heinz</creator><creator>Kleinsasser, Axel</creator><creator>Kotzinger, Oskar</creator><creator>Ulmer, Hanno</creator><creator>Hasibeder, Walter</creator><creator>Knotzer, Hans</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0132-9994</orcidid></search><sort><creationdate>201708</creationdate><title>The impact of endotoxin on jejunal tissue oxygenation</title><author>Pajk, Werner ; Stadlbauer, Karl‐Heinz ; Kleinsasser, Axel ; Kotzinger, Oskar ; Ulmer, Hanno ; Hasibeder, Walter ; Knotzer, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3579-b8489bae28fc53987db7d7553e30a7e7157b24c1fc2b3d921ba19a53ec960b8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Circulatory system</topic><topic>clark‐type surface oxygen electrodes</topic><topic>Endotoxins - pharmacology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Jejunum - blood supply</topic><topic>Jejunum - metabolism</topic><topic>Microcirculation</topic><topic>microcirculatory flowmotion</topic><topic>mucosal oxygen tension</topic><topic>Oxygen - metabolism</topic><topic>Regional Blood Flow</topic><topic>sepsis</topic><topic>Swine</topic><topic>vasomotion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pajk, Werner</creatorcontrib><creatorcontrib>Stadlbauer, Karl‐Heinz</creatorcontrib><creatorcontrib>Kleinsasser, Axel</creatorcontrib><creatorcontrib>Kotzinger, Oskar</creatorcontrib><creatorcontrib>Ulmer, Hanno</creatorcontrib><creatorcontrib>Hasibeder, Walter</creatorcontrib><creatorcontrib>Knotzer, Hans</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pajk, Werner</au><au>Stadlbauer, Karl‐Heinz</au><au>Kleinsasser, Axel</au><au>Kotzinger, Oskar</au><au>Ulmer, Hanno</au><au>Hasibeder, Walter</au><au>Knotzer, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of endotoxin on jejunal tissue oxygenation</atitle><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle><addtitle>Microcirculation</addtitle><date>2017-08</date><risdate>2017</risdate><volume>24</volume><issue>6</issue><epage>n/a</epage><issn>1073-9688</issn><eissn>1549-8719</eissn><abstract>Objective
We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs.
Methods
Jejunal mucosal tissue PO2 was measured employing Clark‐type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated. Systemic hemodynamic variables, mesenteric venous and systemic acid base and blood gas variables, and lactate measurements were recorded. Measurements were taken at BL and after Escherichia coli LPS administration in 20 minutes intervals for 110 minutes.
Results
ETX infusion led to a significant (P<.05) decrease of PO2muc (from 24±4 to 8±4 mm Hg) and microvascular HbO2 (from 41±13 to 24±12%). Microcirculatory conductivity increased in ETX animals, microvascular blood flow remained unchanged (PU; from 228±45 to 232±58). ETX induced an increase in oscillation frequency of mucosal tissue oxygenation.
Conclusions
Endotoxinemia resulted in a significant depression of mucosal tissue oxygenation despite a constant microcirculatory blood flow. This impairment of tissue oxygenation resulted in an increase in the vasomotion pattern in a futile attempt to counteract the undersupply of oxygen to the jejunal tissue.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28477419</pmid><doi>10.1111/micc.12379</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0132-9994</orcidid></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Circulatory system clark‐type surface oxygen electrodes Endotoxins - pharmacology Intestinal Mucosa - metabolism Jejunum - blood supply Jejunum - metabolism Microcirculation microcirculatory flowmotion mucosal oxygen tension Oxygen - metabolism Regional Blood Flow sepsis Swine vasomotion |
| title | The impact of endotoxin on jejunal tissue oxygenation |
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