The impact of endotoxin on jejunal tissue oxygenation

The impact of endotoxin on jejunal tissue oxygenation

Objective We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs. Methods Jejunal mucosal tissue PO2 was measured employing Clark‐type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflect...

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Veröffentlicht in:Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2017-08, Vol.24 (6), p.n/a
Hauptverfasser: Pajk, Werner, Stadlbauer, Karl‐Heinz, Kleinsasser, Axel, Kotzinger, Oskar, Ulmer, Hanno, Hasibeder, Walter, Knotzer, Hans
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Circulatory system
clark‐type surface oxygen electrodes
Endotoxins - pharmacology
Intestinal Mucosa - metabolism
Jejunum - blood supply
Jejunum - metabolism
Microcirculation
microcirculatory flowmotion
mucosal oxygen tension
Oxygen - metabolism
Regional Blood Flow
sepsis
Swine
vasomotion
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Zusammenfassung:Objective We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs. Methods Jejunal mucosal tissue PO2 was measured employing Clark‐type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated. Systemic hemodynamic variables, mesenteric venous and systemic acid base and blood gas variables, and lactate measurements were recorded. Measurements were taken at BL and after Escherichia coli LPS administration in 20 minutes intervals for 110 minutes. Results ETX infusion led to a significant (P
ISSN:1073-9688
1549-8719
DOI:10.1111/micc.12379