Gladiolus dalenii lyophilisate reverses scopolamine-induced amnesia and reduces oxidative stress in rat brain

Highlights • Gladiolus dalenii decreased acetylcholinesterase activity in rat hippocampus and prefrontal cortex. • Gladiolus dalenii decreased malondialdehyde in the hippocampus. • Gladiolus dalenii increased glutathione levels in the hippocampus. • Cognitive deficit was improved by the beneficial e...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-07, Vol.91, p.350-357
Hauptverfasser:	Ngoupaye, Gwladys Temkou, Pahaye, David Bougolla, Ngondi, Judith, Moto, Fleur Clarisse Okomolo, Bum, Elisabeth Ngo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Amnesia Amnesia - chemically induced Amnesia - drug therapy Animals Antioxidant Brain - pathology Freeze Drying Gladiolus dalenii Glutathione - metabolism Hippocampus - drug effects Hippocampus - enzymology Hippocampus - metabolism Hippocampus - pathology Internal Medicine Iridaceae - chemistry Male Malondialdehyde - metabolism Maze Learning - drug effects Medical Education Memory - drug effects Oxidative Stress - drug effects Plant Extracts - pharmacology Plant Extracts - therapeutic use Prefrontal Cortex - drug effects Prefrontal Cortex - embryology Prefrontal Cortex - pathology Rats, Wistar Recognition (Psychology) Scopolamine Scopolamine Hydrobromide Task Performance and Analysis
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Zusammenfassung:	Highlights • Gladiolus dalenii decreased acetylcholinesterase activity in rat hippocampus and prefrontal cortex. • Gladiolus dalenii decreased malondialdehyde in the hippocampus. • Gladiolus dalenii increased glutathione levels in the hippocampus. • Cognitive deficit was improved by the beneficial effect of Gladiolus dalenii.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2017.04.061