Knockout of sodium pump α3 subunit gene ( Atp1a3-/- ) results in perinatal seizure and defective respiratory rhythm generation
Highlights • The mRNA of Atp1a3 is expressed in almost all regions in the neonatal mouse brain. • About half of Atp1a3-/- fetuses showed seizures immediately after birth. • Expression of c-Fos signal in the cerebellum was unique in Atp1a3-/-. • Increased monoamine content was observed in the Atp1a3-...
Gespeichert in:
| Veröffentlicht in: | Brain research 2017-07, Vol.1666, p.27-37 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 37 |
|---|---|
| container_issue | |
| container_start_page | 27 |
| container_title | Brain research |
| container_volume | 1666 |
| creator | Ikeda, Keiko Onimaru, Hiroshi Kawakami, Kiyoshi |
| description | Highlights • The mRNA of Atp1a3 is expressed in almost all regions in the neonatal mouse brain. • About half of Atp1a3-/- fetuses showed seizures immediately after birth. • Expression of c-Fos signal in the cerebellum was unique in Atp1a3-/-. • Increased monoamine content was observed in the Atp1a3-/- brains. • Atp1a3-/- showed various abnormal respiratory rhythms as recorded from phrenic nerve. |
| doi_str_mv | 10.1016/j.brainres.2017.04.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1894915285</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0006899317301750</els_id><sourcerecordid>1894915285</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-fb20efb319bbe03d2ccd4ab43ffd48c8f2475fee6723250a34954b7567fbc833</originalsourceid><addsrcrecordid>eNqFkrtuFDEUhkcIRJbAK0QuQzEb3-bWIKKIACISBekt23NMvJmxB18ibRqeKS_CM-FhEwoaKsvWd_5f_nSq6oTgLcGkPdttVZDWBYhbikm3xXyLCX9WbUjf0bqlHD-vNhjjtu6HgR1Vr2LclStjA35ZHdGetw2l_ab6-cV5fetzQt6g6EebZ7TkeUG_HhiKWWVnE_oODtApOk8Lkaw-q9FbVIrzlCKyDi0QrJNJTiiCvc8BkHQjGsGATvYOVnSxQSYf9ijc7NPN_CewvFjvXlcvjJwivHk8j6vryw_XF5_qq68fP1-cX9Wa90OqjaIYjGJkUAowG6nWI5eKM2NG3uveUN41BqDtKKMNlowPDVdd03ZG6Z6x4-r0ELsE_yNDTGK2UcM0SQc-R0H6gQ-koX1T0PaA6uBjDGDEEuwsw14QLFb3Yiee3IvVvcBcFPdl8OSxI6sZxr9jT7IL8P4AQPnonYUgorbgNIw2FFdi9Pb_He_-idCTdVbL6Rb2EHc-B1c0CiIiFVh8WzdgXQDSsZLSYPYbuVqwBQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1894915285</pqid></control><display><type>article</type><title>Knockout of sodium pump α3 subunit gene ( Atp1a3-/- ) results in perinatal seizure and defective respiratory rhythm generation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ikeda, Keiko ; Onimaru, Hiroshi ; Kawakami, Kiyoshi</creator><creatorcontrib>Ikeda, Keiko ; Onimaru, Hiroshi ; Kawakami, Kiyoshi</creatorcontrib><description>Highlights • The mRNA of Atp1a3 is expressed in almost all regions in the neonatal mouse brain. • About half of Atp1a3-/- fetuses showed seizures immediately after birth. • Expression of c-Fos signal in the cerebellum was unique in Atp1a3-/-. • Increased monoamine content was observed in the Atp1a3-/- brains. • Atp1a3-/- showed various abnormal respiratory rhythms as recorded from phrenic nerve.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2017.04.014</identifier><identifier>PMID: 28465228</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Atp1a3 ; c-Fos ; Hemiplegia - genetics ; Mice, Knockout ; Monoamine ; Mutation - genetics ; Neurology ; Phenotype ; Respiratory Rate - drug effects ; Respiratory Rate - genetics ; Respiratory rhythm ; Seizure ; Seizures - genetics ; Seizures - physiopathology ; Sodium pump ; Sodium-Potassium-Exchanging ATPase - deficiency ; Sodium-Potassium-Exchanging ATPase - genetics ; Sodium-Potassium-Exchanging ATPase - metabolism</subject><ispartof>Brain research, 2017-07, Vol.1666, p.27-37</ispartof><rights>Elsevier B.V.</rights><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-fb20efb319bbe03d2ccd4ab43ffd48c8f2475fee6723250a34954b7567fbc833</citedby><cites>FETCH-LOGICAL-c489t-fb20efb319bbe03d2ccd4ab43ffd48c8f2475fee6723250a34954b7567fbc833</cites><orcidid>0000-0003-4864-8597</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2017.04.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28465228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikeda, Keiko</creatorcontrib><creatorcontrib>Onimaru, Hiroshi</creatorcontrib><creatorcontrib>Kawakami, Kiyoshi</creatorcontrib><title>Knockout of sodium pump α3 subunit gene ( Atp1a3-/- ) results in perinatal seizure and defective respiratory rhythm generation</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Highlights • The mRNA of Atp1a3 is expressed in almost all regions in the neonatal mouse brain. • About half of Atp1a3-/- fetuses showed seizures immediately after birth. • Expression of c-Fos signal in the cerebellum was unique in Atp1a3-/-. • Increased monoamine content was observed in the Atp1a3-/- brains. • Atp1a3-/- showed various abnormal respiratory rhythms as recorded from phrenic nerve.</description><subject>Animals</subject><subject>Atp1a3</subject><subject>c-Fos</subject><subject>Hemiplegia - genetics</subject><subject>Mice, Knockout</subject><subject>Monoamine</subject><subject>Mutation - genetics</subject><subject>Neurology</subject><subject>Phenotype</subject><subject>Respiratory Rate - drug effects</subject><subject>Respiratory Rate - genetics</subject><subject>Respiratory rhythm</subject><subject>Seizure</subject><subject>Seizures - genetics</subject><subject>Seizures - physiopathology</subject><subject>Sodium pump</subject><subject>Sodium-Potassium-Exchanging ATPase - deficiency</subject><subject>Sodium-Potassium-Exchanging ATPase - genetics</subject><subject>Sodium-Potassium-Exchanging ATPase - metabolism</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkrtuFDEUhkcIRJbAK0QuQzEb3-bWIKKIACISBekt23NMvJmxB18ibRqeKS_CM-FhEwoaKsvWd_5f_nSq6oTgLcGkPdttVZDWBYhbikm3xXyLCX9WbUjf0bqlHD-vNhjjtu6HgR1Vr2LclStjA35ZHdGetw2l_ab6-cV5fetzQt6g6EebZ7TkeUG_HhiKWWVnE_oODtApOk8Lkaw-q9FbVIrzlCKyDi0QrJNJTiiCvc8BkHQjGsGATvYOVnSxQSYf9ijc7NPN_CewvFjvXlcvjJwivHk8j6vryw_XF5_qq68fP1-cX9Wa90OqjaIYjGJkUAowG6nWI5eKM2NG3uveUN41BqDtKKMNlowPDVdd03ZG6Z6x4-r0ELsE_yNDTGK2UcM0SQc-R0H6gQ-koX1T0PaA6uBjDGDEEuwsw14QLFb3Yiee3IvVvcBcFPdl8OSxI6sZxr9jT7IL8P4AQPnonYUgorbgNIw2FFdi9Pb_He_-idCTdVbL6Rb2EHc-B1c0CiIiFVh8WzdgXQDSsZLSYPYbuVqwBQ</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Ikeda, Keiko</creator><creator>Onimaru, Hiroshi</creator><creator>Kawakami, Kiyoshi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4864-8597</orcidid></search><sort><creationdate>20170701</creationdate><title>Knockout of sodium pump α3 subunit gene ( Atp1a3-/- ) results in perinatal seizure and defective respiratory rhythm generation</title><author>Ikeda, Keiko ; Onimaru, Hiroshi ; Kawakami, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-fb20efb319bbe03d2ccd4ab43ffd48c8f2475fee6723250a34954b7567fbc833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Atp1a3</topic><topic>c-Fos</topic><topic>Hemiplegia - genetics</topic><topic>Mice, Knockout</topic><topic>Monoamine</topic><topic>Mutation - genetics</topic><topic>Neurology</topic><topic>Phenotype</topic><topic>Respiratory Rate - drug effects</topic><topic>Respiratory Rate - genetics</topic><topic>Respiratory rhythm</topic><topic>Seizure</topic><topic>Seizures - genetics</topic><topic>Seizures - physiopathology</topic><topic>Sodium pump</topic><topic>Sodium-Potassium-Exchanging ATPase - deficiency</topic><topic>Sodium-Potassium-Exchanging ATPase - genetics</topic><topic>Sodium-Potassium-Exchanging ATPase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeda, Keiko</creatorcontrib><creatorcontrib>Onimaru, Hiroshi</creatorcontrib><creatorcontrib>Kawakami, Kiyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeda, Keiko</au><au>Onimaru, Hiroshi</au><au>Kawakami, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Knockout of sodium pump α3 subunit gene ( Atp1a3-/- ) results in perinatal seizure and defective respiratory rhythm generation</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>1666</volume><spage>27</spage><epage>37</epage><pages>27-37</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Highlights • The mRNA of Atp1a3 is expressed in almost all regions in the neonatal mouse brain. • About half of Atp1a3-/- fetuses showed seizures immediately after birth. • Expression of c-Fos signal in the cerebellum was unique in Atp1a3-/-. • Increased monoamine content was observed in the Atp1a3-/- brains. • Atp1a3-/- showed various abnormal respiratory rhythms as recorded from phrenic nerve.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28465228</pmid><doi>10.1016/j.brainres.2017.04.014</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4864-8597</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2017-07, Vol.1666, p.27-37 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1894915285 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Atp1a3 c-Fos Hemiplegia - genetics Mice, Knockout Monoamine Mutation - genetics Neurology Phenotype Respiratory Rate - drug effects Respiratory Rate - genetics Respiratory rhythm Seizure Seizures - genetics Seizures - physiopathology Sodium pump Sodium-Potassium-Exchanging ATPase - deficiency Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism |
| title | Knockout of sodium pump α3 subunit gene ( Atp1a3-/- ) results in perinatal seizure and defective respiratory rhythm generation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T09%3A12%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Knockout%20of%20sodium%20pump%20%CE%B13%20subunit%20gene%20(%20Atp1a3-/-%20)%20results%20in%20perinatal%20seizure%20and%20defective%20respiratory%20rhythm%20generation&rft.jtitle=Brain%20research&rft.au=Ikeda,%20Keiko&rft.date=2017-07-01&rft.volume=1666&rft.spage=27&rft.epage=37&rft.pages=27-37&rft.issn=0006-8993&rft.eissn=1872-6240&rft_id=info:doi/10.1016/j.brainres.2017.04.014&rft_dat=%3Cproquest_cross%3E1894915285%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1894915285&rft_id=info:pmid/28465228&rft_els_id=1_s2_0_S0006899317301750&rfr_iscdi=true |