Knockout of sodium pump α3 subunit gene ( Atp1a3-/- ) results in perinatal seizure and defective respiratory rhythm generation

Highlights • The mRNA of Atp1a3 is expressed in almost all regions in the neonatal mouse brain. • About half of Atp1a3-/- fetuses showed seizures immediately after birth. • Expression of c-Fos signal in the cerebellum was unique in Atp1a3-/-. • Increased monoamine content was observed in the Atp1a3-...

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Veröffentlicht in:	Brain research 2017-07, Vol.1666, p.27-37
Hauptverfasser:	Ikeda, Keiko, Onimaru, Hiroshi, Kawakami, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atp1a3 c-Fos Hemiplegia - genetics Mice, Knockout Monoamine Mutation - genetics Neurology Phenotype Respiratory Rate - drug effects Respiratory Rate - genetics Respiratory rhythm Seizure Seizures - genetics Seizures - physiopathology Sodium pump Sodium-Potassium-Exchanging ATPase - deficiency Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism
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Zusammenfassung:	Highlights • The mRNA of Atp1a3 is expressed in almost all regions in the neonatal mouse brain. • About half of Atp1a3-/- fetuses showed seizures immediately after birth. • Expression of c-Fos signal in the cerebellum was unique in Atp1a3-/-. • Increased monoamine content was observed in the Atp1a3-/- brains. • Atp1a3-/- showed various abnormal respiratory rhythms as recorded from phrenic nerve.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2017.04.014