The role of AMPK in T cell metabolism and function

Highlights • AMPK is activated by immune and environmental stimuli in T cells. • AMPK regulates T cell fuel usage in response to nutrient availability. • AMPK control of metabolism can direct T cell fate. • AMPK control of T cell metabolic fitness may influence anti-tumor immunity.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in immunology 2017-06, Vol.46, p.45-52
Hauptverfasser:	Ma, Eric H, Poffenberger, Maya C, Wong, Alison H-T, Jones, Russell G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology AMP-Activated Protein Kinases - metabolism Animals Cell Differentiation - immunology Energy Metabolism Humans Immunomodulation Lymphocyte Activation - immunology Mitochondria - metabolism Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Signal Transduction T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism
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Beschreibung
Zusammenfassung:	Highlights • AMPK is activated by immune and environmental stimuli in T cells. • AMPK regulates T cell fuel usage in response to nutrient availability. • AMPK control of metabolism can direct T cell fate. • AMPK control of T cell metabolic fitness may influence anti-tumor immunity.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2017.04.004