Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is expressed in the brain. Here we show that intracerebroventricular (i.c.v.) GLP-1 and [Ser(2)]exendin(1–9) (HSEGTFTSD; homologous to a conserved domain in the glucagon/GLP-1 family) enhance associative and s...

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Veröffentlicht in:	Nature medicine 2003-09, Vol.9 (9), p.1173-1179
Hauptverfasser:	During, Matthew J, Cao, Lei, Zuzga, David S, Francis, Jeremy S, Fitzsimons, Helen L, Jiao, Xiangyang, Bland, Ross J, Klugmann, Matthias, Banks, William A, Drucker, Daniel J, Haile, Colin N
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Amino Acid Sequence Animals Apoptosis - drug effects Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Cancer Research Cognition - drug effects Gene Expression Gene Transfer Techniques Glucagon - administration & dosage Glucagon - pharmacology Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology Infectious Diseases Kainic Acid - adverse effects Learning - drug effects Learning - physiology Male Metabolic Diseases Mice Mice, Knockout Molecular Medicine Molecular Sequence Data Neurons - drug effects Neurons - pathology Neuroprotective Agents - pharmacology Neurosciences Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Protein Precursors - administration & dosage Protein Precursors - pharmacology Rats Rats, Sprague-Dawley Receptors, Glucagon - drug effects Receptors, Glucagon - genetics Receptors, Glucagon - metabolism Seizures - chemically induced Seizures - genetics Sequence Homology, Amino Acid Signal Transduction
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