Simultaneous quantification of batrachotoxin and epibatidine in plasma by ultra-performance liquid chromatography/tandem mass spectrometry

Highlights • UPLC-MS/MS was used for quantification of batrachotoxin and epibatidine in plasma. • This method was also applied for quantification of batrachotoxin and epibatidine in rat plasma. • This is the first report using UPLC-MS/MS to quantify these toxins in plasma.

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Bibliographische Detailangaben
Veröffentlicht in:	Legal medicine (Tokyo, Japan) Japan), 2017-03, Vol.25, p.1-5
Hauptverfasser:	Shiraishi, Yosuke, Ogawa, Tadashi, Suzuki, Takayoshi, Iwai, Masae, Kusano, Maiko, Zaitsu, Kei, Kondo, Fumio, Ishii, Akira, Seno, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Non-Narcotic - blood Analgesics, Non-Narcotic - chemistry Animals Anura Batrachotoxin Batrachotoxins - blood Batrachotoxins - chemistry Bridged Bicyclo Compounds, Heterocyclic - blood Bridged Bicyclo Compounds, Heterocyclic - chemistry Chromatography, High Pressure Liquid - methods Epibatidine Internal Medicine Japan Natural toxins Pyridines - blood Pyridines - chemistry Rats Rats, Wistar Tandem Mass Spectrometry - methods Ultra-performance liquid chromatography/tandem mass spectrometry
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Beschreibung
Zusammenfassung:	Highlights • UPLC-MS/MS was used for quantification of batrachotoxin and epibatidine in plasma. • This method was also applied for quantification of batrachotoxin and epibatidine in rat plasma. • This is the first report using UPLC-MS/MS to quantify these toxins in plasma.
ISSN:	1344-6223 1873-4162
DOI:	10.1016/j.legalmed.2016.12.008