Long-Term Prognostic Value of Appropriate Myocardial Perfusion Imaging

Abstract Appropriate use criteria (AUC) for single-photon emission computed tomography myocardial perfusion images (SPECT-MPI) were developed to address the growth of cardiac imaging studies. Long term prognostic value of AUC in SPECT-MPI has not been tested in existing cohorts. We sought to determine the long term prognostic value of MPI classified as appropriate. AUC was evaluated in a prospectively designed cohort of patients who underwent clinically indicated MPI. MPI studies were classified based on 2009 AUC for SPECT-MPI. Data regarding downstream coronary angiography (cath), revascularization and all-cause mortality, cardiac death and nonfatal myocardial infarction (MI) were collected from national registries. Among n=1129 MPI scans that received an appropriate grading, 148 all-cause deaths, 109 MI, 58 cardiac deaths, 152 caths, 113 revascularization procedures occurred over a mean follow-up period of 5.4 ± 1.2 years (0.9% cardiac death rate per year, 1.8% MI rate per year). Most of the scans were low-risk normal MPI scans (summed stress score ≤3) (74.1%). An abnormal scan was associated with higher rates of MI (19.5% vs 6.2%, HR 1.72, p=0.017) and cardiac death (13.4% vs 2.3%, HR 2.12, p=0.016). In conclusion, MPI scans classified as appropriate have long-term prognostic value, despite a high proportion of low risk scans. This provides support for clinicians to consider the use of appropriate grading in addition to MPI scan results in patient management.