Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the place...

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Veröffentlicht in:	The Journal of pediatrics 2017-07, Vol.186, p.196-199
Hauptverfasser:	Mulkey, Sarah B., MD, PhD, Ramakrishnaiah, Raghu H., MBBS, McKinstry, Robert C., MD, PhD, Chang, Taeun, MD, Mathur, Amit M., MD, Mayock, Dennis E., MD, Van Meurs, Krisa P., MD, Schaefer, G. Bradley, MD, Luo, Chunqiao, MS, Bai, Shasha, PhD, Juul, Sandra E., MD, PhD, Wu, Yvonne W., MD, MPH
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Injuries - diagnostic imaging Brain Injuries - etiology Brain Injuries - pathology brain volumetrics diffusion weighted imaging Double-Blind Method Erythropoietin - therapeutic use Female Humans Hypoxia-Ischemia, Brain - diagnostic imaging Hypoxia-Ischemia, Brain - drug therapy Hypoxia-Ischemia, Brain - pathology Infant Infant, Newborn Magnetic Resonance Imaging Male neuroprotection Neuroprotective Agents - therapeutic use newborn Pediatrics Prospective Studies Time Factors Treatment Outcome United States
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Zusammenfassung:	In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group ( P = .004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov : NCT01913340.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2017.03.053