Splicing regulatory factors, ageing and age-related disease

Highlights • Alternative splicing (AS) is emerging as an important control point of gene expression. • AS allows a single gene to produce several mRNA with diverse biological functions. • AS is deregulated during ageing. • Aberrant AS has deep implications for age-related disease.

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Bibliographische Detailangaben
Veröffentlicht in:	Ageing research reviews 2017-07, Vol.36, p.165-170
Hauptverfasser:	Latorre, Eva, Harries, Lorna. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Aging - pathology Alternative Splicing - physiology Animals Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism Humans Internal Medicine Neurology RNA, Messenger - genetics
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Beschreibung
Zusammenfassung:	Highlights • Alternative splicing (AS) is emerging as an important control point of gene expression. • AS allows a single gene to produce several mRNA with diverse biological functions. • AS is deregulated during ageing. • Aberrant AS has deep implications for age-related disease.
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2017.04.004