Enhancing the Cytotoxic Activity of Anticancer Pt super(IV) Complexes by Introduction of Lonidamine as an Axial Ligand
The synthesis and in vitro cytotoxicity of a series of Pt super(IV) complexes with lonidamine as a ligand coordinated in axial position are described. Lonidamine was found to affect strongly the in vitro cytotoxic activity of these new complexes, lowering the IC sub(50) values down to the nanomolar...
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| Veröffentlicht in: | European journal of inorganic chemistry 2017-03, Vol.2017 (12), p.1785-1791 |
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| container_end_page | 1791 |
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| container_issue | 12 |
| container_start_page | 1785 |
| container_title | European journal of inorganic chemistry |
| container_volume | 2017 |
| creator | Nosova, Yulia N Foteeva, Lidia S Zenin, Ilia V Fetisov, Timur I Kirsanov, Kirill I Yakubovskaya, Marianna G Antonenko, Taisya A Tafeenko, Viktor A Aslanov, Leonid A Lobas, Anna A Gorshkov, Mikhail V Galanski, Markus Keppler, Bernhard K Timerbaev, Andrei R Milaeva, Elena R Nazarov, Alexey A |
| description | The synthesis and in vitro cytotoxicity of a series of Pt super(IV) complexes with lonidamine as a ligand coordinated in axial position are described. Lonidamine was found to affect strongly the in vitro cytotoxic activity of these new complexes, lowering the IC sub(50) values down to the nanomolar range. Lipophilicity assessed in terms of logP showed no direct correlation with cytotoxicity. A series of Pt super(IV) complexes with lonidamine as a ligand coordinated in axial position is reported. Lonidamine affects strongly the in vitro cytotoxic activity, lowering the IC sub(50) values down to the nanomolar range. |
| doi_str_mv | 10.1002/ejic.201600857 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1434-1948 |
| ispartof | European journal of inorganic chemistry, 2017-03, Vol.2017 (12), p.1785-1791 |
| issn | 1434-1948 1099-0682 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1893916846 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Anticancer properties Correlation In vitro testing Ligands Lipophilicity Nanostructure Synthesis Toxicity |
| title | Enhancing the Cytotoxic Activity of Anticancer Pt super(IV) Complexes by Introduction of Lonidamine as an Axial Ligand |
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