Suspended Manufacture of Biological Structures

A method for the production of complex cell‐laden structures is reported, which allows high‐levels of spatial control over mechanical and chemical properties. The potential of this method for producing complicated tissues is demonstrated by manufacturing a complex hard/soft tissue interface and demo...

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Veröffentlicht in:	Advanced materials (Weinheim) 2017-04, Vol.29 (13), p.np-n/a
Hauptverfasser:	Moxon, Samuel R., Cooke, Megan E., Cox, Sophie C., Snow, Martyn, Jeys, Lee, Jones, Simon W., Smith, Alan M., Grover, Liam M.
Format:	Artikel
Sprache:	eng
Schlagworte:	additive layer manufacturing cartilage Cartilage - cytology Cartilage - physiology Cell Survival Chemical properties Chondrocytes - cytology Chondrocytes - physiology Coculture Techniques Computer Simulation Culture Elasticity Femur - cytology Femur - physiology Humans hydrogels Hydrogels - chemistry Materials Testing Models, Biological Osteoblasts - cytology Osteoblasts - physiology osteochondral Polymers - chemistry Rheology RNA, Messenger - metabolism Soft tissues Suspensions - chemistry tissue engineering Tissue Engineering - methods Tissue Scaffolds Viscosity X-Ray Microtomography
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Beschreibung
Zusammenfassung:	A method for the production of complex cell‐laden structures is reported, which allows high‐levels of spatial control over mechanical and chemical properties. The potential of this method for producing complicated tissues is demonstrated by manufacturing a complex hard/soft tissue interface and demonstrating that cell phenotype can be maintained over four weeks of culture.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201605594