Bringing proteins into the fold

A molecular origami method uses double-stranded DNA scaffolds and protein staples to create hybrid nanostructures Molecular engineers have become increasingly adept at repurposing life's building blocks to make custom self-assembled shapes. Because a single drop of solution contains billions of such shapes, DNA origami smiley faces ( 1 ), RNA stars ( 2 ), and designer protein polyhedra ( 3 ) may vastly outnumber most other human-made objects on Earth. These shapes lack immediate practical utility, but they transmit a powerful message: Researchers are beginning to understand how molecules self-assemble. On page 1283 of this issue, Praetorius and Dietz make another leap forward by demonstrating a novel class of nanostructures, namely DNA-protein hybrid shapes ( 4 ). This is an important advance because it provides a method to create human-designed shapes out of ingredients that are generally compatible with living systems.