Oxidative Heck desymmetrisation of 2,2-disubstituted cyclopentene-1,3-diones

Oxidative Heck desymmetrisation of 2,2-disubstituted cyclopentene-1,3-diones

Oxidative Heck couplings have been successfully developed for 2,2-disubstituted cyclopentene-1,3-diones. The direct coupling onto the 2,2-disubstituted cyclopentene-1,3-dione core provides a novel expedient way of enantioselectively desymmetrising all-carbon quaternary centres.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-03, Vol.51 (19), p.4089-4092
Hauptverfasser: Walker, S E, Lamb, C J C, Beattie, N A, Nikodemiak, P, Lee, A-L
Format: Artikel
Sprache:eng
Schlagworte:
Couplings
Cyclopentanes - chemistry
Ketones - chemistry
Oxidation-Reduction
Stereoisomerism
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Zusammenfassung:Oxidative Heck couplings have been successfully developed for 2,2-disubstituted cyclopentene-1,3-diones. The direct coupling onto the 2,2-disubstituted cyclopentene-1,3-dione core provides a novel expedient way of enantioselectively desymmetrising all-carbon quaternary centres.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc00407a