Iron catalysed cross-couplings of azetidines - application to the formal synthesis of a pharmacologically active molecule

Iron catalysed cross-couplings of azetidines - application to the formal synthesis of a pharmacologically active molecule

A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a s...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-02, Vol.51 (11), p.2111-2113
Hauptverfasser: Parmar, Dixit, Henkel, Lena, Dib, Josef, Rueping, Magnus
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Azetidines - chemistry
Catalysis
Catalysts
Central Nervous System Agents - chemical synthesis
Central Nervous System Agents - chemistry
Chemistry Techniques, Synthetic
Coupling
Cross coupling
Iron
Iron - chemistry
Pharmacology
Reagents
Synthesis (chemistry)
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Beschreibung
Zusammenfassung:A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a short formal synthesis towards a pharmacologically active molecule was shown.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc09337b