Azobenzene-based chloride transporters with light-controllable activities

Synthetic chloride transporters containing two urea groups linked through a diazobenzene spacer have been prepared and the trans-to-cis isomerization by light stimulation results in dramatic changes in the chloride transport activities across lipid and cell membranes.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-12, Vol.50 (97), p.15305-15308
Hauptverfasser:	Choi, Ye Rin, Kim, Gyu Chan, Jeon, Hae-Geun, Park, Jinhong, Namkung, Wan, Jeong, Kyu-Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azo Compounds - chemistry Azo Compounds - radiation effects Biological Transport Cell Line Cell Membrane - metabolism Chlorides Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Carriers - radiation effects Isomerism Lipids Membranes Rats, Inbred F344 Sodium Chloride - administration & dosage Sodium Chloride - chemistry Sodium Chloride - pharmacokinetics Spacers Stimulation Transport Ultraviolet Rays Urea - chemistry Ureas
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Beschreibung
Zusammenfassung:	Synthetic chloride transporters containing two urea groups linked through a diazobenzene spacer have been prepared and the trans-to-cis isomerization by light stimulation results in dramatic changes in the chloride transport activities across lipid and cell membranes.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c4cc07560a